Content validity was reported in 89 studies. SELENA SLEDAI4. et al. No study has evaluated the feasibility of the PGA in SLE to date. Different definitions of PGA retrieved through the literature search are reported in Table1. SLE3. Reliability measures the reproducibility of the instrument: it refers to the degree of agreement between different observers (interrater) and in the same observer over time (intrarater). Intoduction to X 20 - Physician Global Assessment Devilliers H Bethesda, MD 20894, Web Policies , Petri MA , Garabajiu M PGA is often assessed by a single question with a 0-10 or 0 . , Hearth-Holmes M. Khan A LECTURE 10: MEDICAL SURGICAL NURSING. Introduction Physician global assessments of disease activity (medical doctor (MD) globals) are important outcomes. Meta-analysis of the studies reporting data concerning the construct validity between the PGA and SLEDAI. , Andreoli L et al. This site needs JavaScript to work properly. , Landis RC , Gallacher AE Newark, New Castle, USA, March 03, 2023 (GLOBE NEWSWIRE) -- The global complement-targeted therapeutics market is expected to grow at a CAGR of 8.9% from 2022 to 2030, owing to the rising . It can affect the joints, skin, brain, lungs, kidneys, and blood vessels. , Bocci EB Once two investigators (E.C., M.P.) AU - Louthrenoo, Worawit. Measurement properties of the PGA were analysed according to the COnsensus-based Standards for the selection of health Measurement INstruments (COSMIN) terminology [19]. In one study, the PGA was part of a modified score to assess disease activity in pregnancy (the SLE in Pregnancy Disease Activity Index) [51]. , Wallace DJ Even though the PGA showed optimal reliability, a very low interRR for flare using the PGA (ICC=0.18) was found in a single study [65] compared with that of the BILAG (ICC=0.54) or SFI (ICC=0.21). Mok CC A PGA >1 was predictive of polymorphic light cutaneous eruption (P=0.02) [59] and correlated negatively with LLDAS attainment [37]. Stojan G Different scores and lengths of visual evaluation were employed: the first was the 010 VAS suggested by Liang et al. Help us improve CareerBuilder by providing feedback about this job: Report this job Job ID: 2281236908. et al. , Morabito LM A prospective cohort study, Validity and reliability of retrospective assessment of disease activity and flare in observational cohorts of lupus patients, A novel lupus activity index accounting for glucocorticoids: SLEDAI-2K glucocorticoid index, Low disease activityirrespective of serologic status at baselineassociated with reduction of corticosteroid dose and number of flares in patients with systemic lupus erythematosus treated with belimumab: a real-life observational study, Definition and initial validation of a lupus low disease activity state (LLDAS), A framework for remission in SLE: consensus findings from a large international task force on definitions of remission in SLE (DORIS), Prolonged remission in Caucasian patients with SLE: prevalence and outcomes, 2019 update of the EULAR recommendations for the management of systemic lupus erythematosus, PRISMA Group. Myelogram - correct answer NPO for 4-6 hours. In the last 30years, more than a dozen scores have been derived to assess disease activity in SLE, but not all of these have proven to be valid and reliable tools. , Petri M. Foering K Psychometric properties of FACIT-Fatigue in systemic lupus erythematosus: a pooled analysis of three phase 3 randomised, double-blind, parallel-group controlled studies (BLISS-SC, BLISS-52, BLISS-76). , Gordon C PMC Franklyn K government site. [80] considered worsening as any increase in the PGA from baseline; in the epratuzumab trial [87], a significant improvement was a 20% decrease in the PGA score evaluated after 12months of treatment. All clinical diagnoses were verified by review of the patients' inpatient and outpatient files at the time of capillaroscopy. COSMIN Terminology from a European Rheumatology Perspective: a Glossary for the EULAR PRO Tool Box Initiative. , Bresee C Thousand Oaks. Several definitions of minimum clinically important difference were retrieved: in the SRI-4, a significant worsening was defined as an increase of >10% on the PGA-VAS [111], corresponding to 0.3 points from baseline; Touma et al. , Tugwell P Criterion validity was assessed exploring the PGA correlation with quality of life measurements, biomarker levels and treatment changes in 28 studies, while no study has evaluated correlation with damage. However, it was used as a single outcome measure only in two studies [49, 100], while in the majority the PGA was scored together with another instrument (typically the SLEDAI) [2, 9, 11, 12, 21, 24, 30, 32, 34, 3740, 44, 45, 48, 49, 55, 58, 59, 61, 63, 64, 66, 67, 74, 75, 80, 82, 86, 8995, 103]. , Perez-Gutthann S et al. Use of Physician Global Assessment in systemic lupus erythematosus: a Construct validity. SLE has protean and often complex manifestations, necessitating careful clinical assessment. et al. Thank you for submitting a comment on this article. Genetic linkage has related dysfunction of . PGA responsiveness was used to assess flare [9]: PGA was identified as the gold standard to rate the exacerbation of lupus activity [21, 67, 88], preliminarily defined by a change of 1.0 on a 03 VAS since the last visit. et al. Derivatives RWA Production Controller (SA-CCR/SLE) et al. PGA is a valid, responsive and feasible instrument, though its reliability was impacted by the scale adopted, suggesting the major need for standardization of its scoring. , Beaumont JL Methods We determined the variability of MD globals, surveying rheumatologists from the Canadian Rheumatology Association using rheumatoid . However, it is important to remember that not all clinical problems reported by a lupus patient are due to the disease. PGA - Lupus Research Ragai Kiriakos, MD, MSc - Clinical Trials Physician - LinkedIn The aim of this systematic literature review is to describe and analyse the . Aranow C , Schur PH. Frontiers | Cutaneous lupus erythematosus disease assessment Additional papers were obtained by checking the references from the selected studies. , Ibanez D Mayara Torres Silva de Oliveira, MD, MBA on LinkedIn: #medicinanuclear et al. , Klein-Gitelman MS , Beresford MW Visual analogue scales (VAS) allow rapid, continuous scaling of disease severity. The measurements were in the form of a scale from 0 to 3 in 54 studies [2, 3, 9, 10, 12, 13, 21, 2469, 103], a 010 scale in 12 studies [4, 60, 7079], a 0100 scale in 9 studies [27, 40, 78, 8085], a 07 Likert scale [11, 78, 80], a 02 scale [53], a 04 scale [86] and a 05 scale [87]. , Trendelenburg M It is therefore desirable to use the PGA along with other tools (typically the SLEDAI) or to include the PGA in a composite index (e.g. The judgment of whether a patient with SLE has active disease is a central question both in routine patient management and in clinical research [4]. , Brunetta P , Stavrakis S The Validity of Patient and Physician Global Disease Activity The PGA is usually reported by experts as allowing exhaustive coverage of the concept of disease activity in SLE [20, 108]. et al. It operates in Albuquerque, and New Mexico. This concept includes content validity, face validity, construct validity and criterion validity. BATCH RUBY INTENSIVE REVIEWRTRMF 3. [84] expressed the sensitivity in PGA scoring with the standardized response mean (SRM), demonstrating a very large effect size (ES=2.23) [110]. 2014 Dec;53(12):2175-81. doi: 10.1093/rheumatology/keu153. In the absence of a well-recognized gold standard for disease activity, criterion validity of the PGA is established when it correlates with a measure that the author of the study defined a priori as the gold standard. Few studies reported on whether serological activity should be incorporated in the PGA. European League Against Rheumatism. , Engleman EG An international panel of 79 SLE experts participated in a three-round Delphi consensus . Published by Oxford University Press on behalf of the British Society for Rheumatology. It estimates how similar a given patients scores were at the two visits. Dynabook PX1900E-1NCA, PROTECTIVE SLE (PX1900E-1NCA) Data regarding divergent validity are lacking for the PGA. Exagen's products are used for therapeutic drug monitoring of hydroxychloroquine in whole blood and methotrexate polyglutamates, risk assessment testing, anti-TNF monitoring to individualize therapy and optimize dosing, and others. Gandhi N , Hambleton IR , Khamashta MA Your recommendations as to what might or should be done in relation to various issues observed. JSS Medical Research. Methods: This systematic literature review was conducted by two independent reviewers in accordance with the Preferred Reporting Items . Content validity was reported in 89 studies. Manzi S , Bertsias G , Matos A et al. Published by Oxford University Press on behalf of the British Society for Rheumatology. Medizinische Universitt Graz Austria/sterreich - Forschungsportal - Medical University of Graz Direkt zur Navigaton springen . For full access to this pdf, sign in to an existing account, or purchase an annual subscription. antineutrophil cytoplasmic antibody-associated vasculitis (AAV), and systemic lupus erythematosus (SLE). Mokkink LB This systematic literature review was conducted by two independent reviewers in accordance with the Preferred Reporting Items for Systematic Reviews and Meta-Analyses statement. , Skogh T One study showed a significant ability of the PGA in distinguishing between patients (P<0.0001) and observers (P<0.0001), but not between visits [79]. The Systemic Lupus Activity Measure-revised, the Mexican Systemic Lupus Erythematosus Disease Activity Index (SLEDAI), and a modified SLEDAI-2K are adequate instruments to measure disease activity in systemic lupus erythematosus. physician's global assessment (PGA) of disease activity in SLE. 2022 May;9(1):e000700. In conclusion, the PGA was demonstrated to be a valid, responsive and feasible instrument, but its reliability was strongly impacted by the scale adopted, suggesting the need for standardization in its scoring. Injuries requiring medical treatment are considered to be "reportable incidents," and must be reported to the NJDOE within five working days of the occurrence. et al. Physician global assessments for disease activity in rheumatoid arthritis are all over the map! Int J Environ Res Public Health. A total of 91 articles were included in the study (Fig. Face validity was reported in all the articles retrieved in which the PGA was used alone or as part of composite indices (Systemic Responder Index, Safety of Estrogen in Lupus Erythematosus National Assessment Flare Index, Lupus Low Disease Activity State, Definitions of Remission in Systemic Lupus Erythematosus criteria). This week's edition of Faculty Publications includes Cedars-Sinai studies that were published Feb. 23-March 2. Accessibility A good responsiveness for PGA was shown in eight studies. Supervise the development of junior medical affairs staff . et al. Associations between physicians' global assessment of disease activity Ann Rheum Dis 2011;70:54-9. We analysed the performance of the SELENA SLEDAI Physician's Global Assessment (SSPGA) and the Lupus Foundation of America-Rapid Evaluation of Activity in Lupus (LFA-REAL) as measures . , Carpenter AB The literature search identified 91 studies. , Klein-Gitelman MS Flow chart illustrating the literature search and study selection. [8] and adopted in childhood SLE; the most common tool (the 03 VAS) was developed [68] to capture the concept of flare and is measured on a 3cm VAS in the SRI [3] and a 10cm VAS in the SFI [10, 104], but other scores (02, 04, 05, 07) [11, 53, 78, 80, 86, 87] and lengths (8cm, 15cm) [10, 8284] have also been used. PGA; disease activity; physician global assessment; psychometrics; systemic lupus erythematosus. A new tool -- the Lupus Activity Scoring Tool (LAST) - has been proposed to join the ranks of current disease activity indices. Objectives Remission in systemic lupus erythematosus (SLE) is defined through a combination of 'clinical SLE Disease Activity Index (cSLEDAI)=0', 'physician's global assessment (PGA) <0.5 . HHS Vulnerability Disclosure, Help PGA or SGA described in ePROVIDE - Mapi Research Trust Criterion validity is defined as the degree to which the scores of an instrument adequately reflect the truth in the form of a gold standard [107]. Exagen Diagnostics Inc (XGN) - Product Pipeline Analysis, 2022 Update , Saad-Magalhes C et al. Merrill JT The 4-point PGA (0, no flare; 1, mild; 2, moderate; 3, severe) showed the lowest IRR in assessing flare (ICC=0.18) compared with the BILAG-2004 (ICC=0.54) and SFI (ICC=0.21) [65]. physician global assessment Recently Published Documents. Enocsson H , Glassman DS Sullivan KE , Wallace DJ et al. Navarra SV et al. Methods This SLR was conducted by two independent reviewers in accordance with the PRISMA statement. Parodis I , Fang H , Mikolaitis-Preuss RA , Magder L Gyri N Arthritis Res Ther. disease activity in SLE, with the Physician Global Assessment (PGA) being the only one included in the updated EULAR recommendations for the management of SLE.11. Systemic lupus erythematosus (SLE), is the most common type of lupus. , Jnsen A The SRI is a validated SLE disease activity instrument used to detect clinically meaningful improvement of disease in SLE clinical trials. Physician Global Assessment International Standardisation COnsensus in Systemic Lupus Erythematosus: the PISCOS study . In our centre, new tools for the assessment of SLE activity: the Lupus Activity Scoring Tool (LAST) and Clinical Lupus Activity Scoring Tool (C-LAST) were developed and validated. The search strategy for SSc-related publications identified 75 citations . Kandane-Rathnayake R, Louthrenoo W, Hoi A, Luo SF, Wu YJ, Chen YH, Cho J, Lateef A, Hamijoyo L, Navarra SV, Zamora L, Sockalingam S, An Y, Li Z, Katsumata Y, Harigai M, Hao Y, Zhang Z, Kikuchi J, Takeuchi T, Basnayake BMDB, Chan M, Ng KPL, Tugnet N, Kumar S, Oon S, Goldblatt F, O'Neill S, Gibson KA, Ohkubo N, Tanaka Y, Bae SC, Lau CS, Nikpour M, Golder V, Morand EF; Asia-Pacific Lupus Collaboration. The anonymous patientcompleted questionnaire comprised the following: current pain in the past 7 days (10cm VAS [0 no pain; 10 most severe pain]), patient global assessment (PtGA) of health status (10 cm VAS [0 very well; 10 very poorly]), ever and current recreational cannabis use, ever and current medical cannabis use, and if cannabis . (SLE) GSKpro global automatic chemiluminescence immunoassay analyzer market INTRODUCTION The chemiluminescence immunoassay system employs magnetic particle separation technology, which employs magnetic particles as antibody carriers and allows for even distribution of the carriers in the liquid phase reaction system, resulting in a faster and more effective . , ODell JR , Borghoff K Three studies evaluated the association between PGA scores and treatment changes: PGA correlated negatively with adherence to treatment assessed through an item scale (r=0.31, P=0.11) [34]; clinically defined mild and moderate flares had a higher disease activity by the PGA (P<0.001) than those defined as mild/moderate flare only by medication changes [55]; PGA scores were associated positively with response to belimumab treatment (P=0.039) [43]. , Adamichou C Oxford Textbook of Neuropsychiatry - 2020 | PDF | Psychiatry Ward et al. A validation study of the SRI for juvenile SLE [60] showed that exclusion of the BILAG or PGA from the SRI did not change the accuracy of the SRI in detecting improvement. , Kalunian K , Raeisi A , Chakravarty E This scoring modality was used for the SRI [3]. To determine longitudinal associations between Physician Global Assessment (PGA) and patient-reported outcomes (PROs) in patients with systemic lupus erythematosus (SLE). Thanks to this feature, the PGA was included in composite indices with the aim of rating manifestations not included in glossary-based instruments such as the SLEDAI and BILAG [3] or for which a threshold has been defined (cytopenia). , Hochberg M. Touma Z Mina R and transmitted securely. Epub 2014 Apr 11. (PGA) scoring of disease activity in systemic lupus erythematosus (SLE). , Ding HH Lai J-S 2022 Sep;8(2):e002395. All articles published through 1 July 2019 in PubMed were screened, with no limitation on year of publication, language or patients' age. Construct validity was demonstrated by a good correlation (r0.50) between the PGA with the SLEDAI (12 studies), SLAM (4 studies), LAI, BILAG and ECLAM (2 studies each).
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